parvo b19

• related: Pediatric

Erythema infectiosum, or fifth disease, is a common, benign childhood illness caused by parvovirus B19. Presentation begins with a nonspecific prodrome (eg, malaise, congestion, cough, fever), followed by an erythematous rash on the cheeks after initial symptoms have resolved. This "slapped-cheek" rash can be described as facial flushing, as in this patient, and usually spares the nasolabial folds. A lacy, reticular rash then follows, spreading over the trunk and extremities and sparing the palms and soles. Diagnosis is clinical. Erythema infectiosum is self-limited, and treatment is supportive.

Parvovirus B19 can also cause arthritis in adults and a transient aplastic crisis in those with underlying hematologic disorders (eg, sickle cell disease).